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E-mail: ĪBSTRACT: Drug interactions (DI) exacerbate the risk of serious adverse events related to the use of benzodiazepines. E-mail: PhD in Public Health, Associate Professor, Pharmacy School, Federal University of Rio de Janeiro. E-mail: Master in Public Health, Risk Manager of the University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro. E-mail: PhD in Public Health, Public Health Technologist at the Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. IPharmacist, Specialist in Hospital Pharmacy, Master Student in Applied Science for Health products, Pharmacy School, Federal University Fluminense.
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Valcieny de Souza Sandes I Guacira Corrêa de Matos II RosanyBochner III Sônia Maria Cezar Góes IV Elisangela da Costa Lima-Dellamora V
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FLUMAZENIL ANTIDOTE DOSE PROFESSIONAL
Your healthcare professional should monitor you for the return of these overdose symptoms while you are being treated with flumazenil. Symptoms include slowed or difficult breathing (respiratory depression). Hypoventilation occurs when the lungs are slowed and are no longer able to perform adequate gas exchange. Your healthcare provider will monitor you for re-sedation following administration of flumazenil. You may experience serious sedation or stupor after administration of flumazenil. Seizures and convulsions are more common if you have taken benzodiazepines for a long period of time. Serious side effects have been reported with flumazenil including the following: Ask your doctor or pharmacist for more information. This is not a complete list of flumazenil drug interactions.
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Flumazenil reverses this activity, which may lead to convulsions, especially when drug overdose has occurred with medications that cause seizures. Benzodiazepines have anti-seizure activity. In the case of drug overdose with multiple drugs, flumazenil should be used with caution. Flumazenil can potentially interact with other central nervous system depressants by blocking their effect. tricyclic antidepressants such as trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline ( Pamelor, Aventyl), protriptyline ( Vivactil), and clomipramine (Anafranil)ĭrug interactions with other central nervous system depressants such as certain narcotics have not been studied specifically.Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
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